The research themes of Caroline Klaver’s research group are the genetic causes and the epidemiology of four eye disorders:

• myopia,
• age-related macular degeneration,
• primary open-angle glaucoma, and
• retinal dystrophies.

The group focuses on identification of genetic causes of eye disorders, environmental risk factors, gene-environment interaction, phenotyping of eye disorders including imaging, prognostic modelling, pathway annotation, and functional studies in animal models.

Various ongoing cohort studies have provided a firm basis for research over the last decade: the population-based Rotterdam Study (N=15,000), family-based ERF study (N=2,600), and the Generation R study (N=7,000).

Other studies of the research group led by Caroline Klaver include the MYST high myopia study (N=1,200), the retinal dystrophy study (N=1,000), the CORRBI biobank for genetic eye diseases (N=4,000), and the GIGA study on Glaucoma in Africa (N=2,500).

Caroline Klaver also leads the international consortium for refractive error (CREAM; N=60,000) and is member of several other consortia for eye diseases (3CC; E3; IGGC; AMDExome).

Visit Caroline Klaver's people page on this website