AUTHORS
Volker Busskamp, Botond Roska, Jose-Alain Sahel
Cold Spring Harb Perspect Med. 2024 Aug 1;14(8):a041660. doi: 10.1101/cshperspect.a041660.
ABSTRACT
Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.
Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 37734866 PMCID: PMC11293536 (available on 2026-08-01) DOI: 10.1101/cshperspect.a041660
