AUTHORS
Xinyu Liu, Liqin Jiang, Mengyuan Ke, Ian A Sigal, Jacqueline Chua, Quan V Hoang, Audrey Wi Chia, Raymond P Najjar, Bingyao Tan, Jocelyn Cheong, Valentina Bellemo, Rachel S Chong, Michaël J A Girard, Marcus Ang, Mengyang Liu, Gerhard Garhöfer, Veluchamy A Barathi, Seang-Mei Saw, Martin Villiger, Leopold Schmetterer
Nat Biomed Eng. 2023 Aug;7(8):986-1000. doi: 10.1038/s41551-023-01062-w. Epub 2023 Jun 26.
ABSTRACT
In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input polarization-sensitive OCT may help establish posterior scleral birefringence as a non-invasive biomarker for assessing the progression of myopia.
PMID:37365268 | PMC:PMC10427432 | DOI:10.1038/s41551-023-01062-w
