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Clinical Data Science and Statistics Platform
In the modern era of biomedical research, clinical and molecular datasets have reached high levels of scale and complexity. Extracting meaningful insights from “big data” requires more than just processing power; it demands deep expertise to ensure that the conclusions drawn are both scientifically sound and statistically robust. The clinical…
Clinical Trial Center Platform
The clinical trial center platform performs clinical trials in ophthalmology, covering both investigator-initiated and industry-sponsored clinical research. It works in close interaction with other IOB groups working on human subject research.
Human Organoid Platform
The human organoid platform generates highly organized human retinal and other organoids from human skin or blood cells in vitro. These organoids are often the starting points for developing gene therapies for patients. The platform can generate tens of thousands of organoids for high throughput screening. The platform generates human…
Single-Cell Genomics Platform
Single cell technologies enable the analysis of thousands of single cells in just one experiment, generating an unprecedented amount of data. The field is less than ten years old and new methods and algorithms for data analysis are being published almost every week. The single-cell genomics platform develops new single-cell…
Complex Viruses Platform
Targeting genes to specific neuronal or glial cell types is essential for developing safe and effective gene therapies for the eye and brain disorders. Adeno-associated viral vectors (AAVs) are the most promising tools for retinal and brain gene therapy, but targeting expression to specific cell types is still a challenge.
Protein Engineering Platform
Over the last decades, protein binders have enabled the development of truly targeted therapies. The protein engineering platform at IOB provides researchers access to highly specific protein binders. These binders are used to develop therapies targeted to specific cell types that are relevant to eye diseases.The core of the platform…
Scientific Computing Platform
The Scientific computing platform employs modern data analysis techniques to extract scientific insights from large datasets. This is accomplished through computer programming, which allows the systematic application of statistical and mathematical methods to perform principled manipulations on the source data. Often, this takes the form of identifying simple underlying structures…